Dr. Sanacora is the George and Ester Gross Professor of Psychiatry, Director of the Yale Depression Research Program, and Co-Director of Yale’s Interventional Psychiatry Program. Dr. Sanacora’s work employs both preclinical and clinical research methodologies in attempts to expand our understanding of the underlying pathophysiology of neuropsychiatric disorders and mechanisms of effective treatment actions, with the goal of ultimately developing novel diagnostic and treatment approaches. He has served as PI on numerous NIH, foundation, and industry sponsored studies ranging from rodent models of pathogenesis, through mechanistic neuroimaging studies introducing novel methods to assess brain metabolism, to large multi-center phase III clinical trials. His personal experience over the arc of this journey has provided him with unique perspectives on the challenges that impede the successful application of neuroscience advances to clinical practice. Most recently, Dr. Sanacora has focused on fostering responsible dissemination efforts, providing leadership to consensus statements and national educational efforts relating to the clinical utility and concerns associated with these novel therapeutic options. In recognition of these efforts, he recently received the 2022 Association for Clinical and Translational Sciences award for Team Science in addition to previous awards including the Anna-Monkia Stiftung international award for investigation of the biological substrate and functional disturbances of depression, the Joel Elkes Research Award for Outstanding contributions to Psychopharmacology from the American College of Neuro-Psychopharmacology.