Although I was born in a suburb of Boston, I was raised in Cincinnati and graduated from the University of Cincinnati with a degree in Biology. I then moved to the West coast to attend Stanford University for medical and graduate school where I studied the structure and function of calcium channels. In 1996, I came to Boston for medical residency at Brigham and Women’s Hospital followed by fellowship training in cardiology and cardiac electrophysiology at Massachusetts General Hospital. In 2001, I joined the faculty at MGH and split my time between research and the clinical care of patients with arrhythmias. In 2016, I became the director of the Demoulas Center for Cardiac Arrhythmias at MGH. At the Broad Institute, I am the Director of the Cardiovascular Research Initiative, and I am a Professor of Medicine at Harvard Medical School. In 2022, I became the interim chief of cardiology and co-director of the Corrigan-Minehan Heart Center at MGH.

I have always been intrigued with human genetics, so my research lab began with an initial focus on trying to identify the genetic basis of atrial fibrillation. My lab is now largely based at the Broad and has now expanded to a wide range of topics that includes cardiovascular disease genetics, disease mechanisms, single cell sequencing, the application of machine learning to cardiac imaging data, and the development of new therapies for cardiovascular diseases.